http://wiki.sseuu.com/index.php?action=history&feed=atom&title=%E4%B8%A4%E7%AF%87%E3%80%8A%E8%87%AA%E7%84%B6%C2%B7%E4%BB%A3%E8%B0%A2%E3%80%8B%EF%BC%9A%E7%A0%B4%E8%A7%A3%E6%8A%97%E8%A1%B0%E8%80%81%E5%88%86%E5%AD%90NAD%2B%E6%B6%88%E5%A4%B1%E4%B9%8B%E8%B0%9C%EF%BC%81%E7%A7%91%E5%AD%A6%E5%AE%B6%E5%8F%91%E7%8E%B0%EF%BC%8C%E8%A1%B0%E8%80%81%E7%BB%86%E8%83%9E%E8%AF%B1%E5%AF%BC%E5%B7%A8%E5%99%AC%E7%BB%86%E8%83%9E%E4%BA%A7%E7%94%9F%E7%9A%84CD38%E6%B6%88%E8%80%97%E4%BA%86NAD%2B 两篇《自然·代谢》：破解抗衰老分子NAD+消失之谜！科学家发现，衰老细胞诱导巨噬细胞产生的CD38消耗了NAD+ - 版本历史 2026-05-09T19:44:02Z 本wiki的该页面的版本历史 MediaWiki 1.30.0 http://wiki.sseuu.com/index.php?title=%E4%B8%A4%E7%AF%87%E3%80%8A%E8%87%AA%E7%84%B6%C2%B7%E4%BB%A3%E8%B0%A2%E3%80%8B%EF%BC%9A%E7%A0%B4%E8%A7%A3%E6%8A%97%E8%A1%B0%E8%80%81%E5%88%86%E5%AD%90NAD%2B%E6%B6%88%E5%A4%B1%E4%B9%8B%E8%B0%9C%EF%BC%81%E7%A7%91%E5%AD%A6%E5%AE%B6%E5%8F%91%E7%8E%B0%EF%BC%8C%E8%A1%B0%E8%80%81%E7%BB%86%E8%83%9E%E8%AF%B1%E5%AF%BC%E5%B7%A8%E5%99%AC%E7%BB%86%E8%83%9E%E4%BA%A7%E7%94%9F%E7%9A%84CD38%E6%B6%88%E8%80%97%E4%BA%86NAD%2B&diff=102391&oldid=prev 2021年5月6日 (四) 23:44 明华 2021-05-06T23:44:17Z <p></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="2" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">2021年5月6日 (四) 23:44的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >第1行：</td> <td colspan="2" class="diff-lineno">第1行：</td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[首页]]&gt;[[通约智库条目|条目]]&gt;[[抗衰老]]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>原创 代丝雨 奇点网 2020-12-18</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>原创 代丝雨 奇点网 2020-12-18</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> </table> 明华 http://wiki.sseuu.com/index.php?title=%E4%B8%A4%E7%AF%87%E3%80%8A%E8%87%AA%E7%84%B6%C2%B7%E4%BB%A3%E8%B0%A2%E3%80%8B%EF%BC%9A%E7%A0%B4%E8%A7%A3%E6%8A%97%E8%A1%B0%E8%80%81%E5%88%86%E5%AD%90NAD%2B%E6%B6%88%E5%A4%B1%E4%B9%8B%E8%B0%9C%EF%BC%81%E7%A7%91%E5%AD%A6%E5%AE%B6%E5%8F%91%E7%8E%B0%EF%BC%8C%E8%A1%B0%E8%80%81%E7%BB%86%E8%83%9E%E8%AF%B1%E5%AF%BC%E5%B7%A8%E5%99%AC%E7%BB%86%E8%83%9E%E4%BA%A7%E7%94%9F%E7%9A%84CD38%E6%B6%88%E8%80%97%E4%BA%86NAD%2B&diff=101377&oldid=prev 2021年4月15日 (四) 05:43 明华 2021-04-15T05:43:05Z <p></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="zh-CN"> <td colspan="2" style="background-color: white; color:black; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">2021年4月15日 (四) 05:43的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >第1行：</td> <td colspan="2" class="diff-lineno">第1行：</td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">原创 代丝雨 奇点网 2020-12-18</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">说起这几年最火的抗衰老元素，那非NAD+莫属——当然，这其中有部分要“归功于”天价却一瓶难求的保健品NMN。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">NAD+，也就是烟酰胺腺嘌呤二核苷酸，是一种氧化还原辅酶，与能量代谢密切相关，在很多研究中都有发现，随着年龄的增长，NAD+水平会逐渐降低，而恢复NAD+水平有助于缓解年龄相关的功能障碍。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">所以补充NAD+就成了抗衰老的大热门。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">我们现在对NAD+到底是怎么来的已经了解得比较透彻了，NMN正是诸多NAD+前体中的性价比之选。但是，NAD+为什么会随着年龄增长消失呢？</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">近期，《自然·代谢》杂志同期发表了两篇论文，为我们揭开了NAD+消失之谜。原来，在衰老组织中，由衰老细胞导致的慢性炎症会诱导M1巨噬细胞中的CD38表达，而CD38正是减少NAD+合成、促进NAD+降解的关键。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">通过senolytics药物消除衰老细胞，则能显著提升NAD+水平。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">看来我们又找到了一个新的抗衰老靶点，CD38！</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">其实之前就有科学家发现，CD38的表达与NAD+水平存在相关性，不过其中有一个令人百思不得其解的问题：大部分CD38位于细胞膜，它的催化位点朝向细胞膜外，而NAD+则主要存在于细胞内部，CD38到底是怎么影响NAD+水平的呢？这个问题被科学家们称作“CD38的拓扑悖论”。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">另一方面，CD38主要表达于免疫细胞中，而众所周知，衰老会带来广泛的慢性炎症，炎性反应很可能会激活免疫细胞，导致衰老组织中CD38的积累。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">研究者对小鼠的组织进行了分析，发现在衰老动物的肝脏和白色脂肪组织中，出现了大量的CD38富集，而这些CD38主要来源于促炎的M1巨噬细胞。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">衰老组织中存在大量的CD38</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">同时，将衰老细胞和巨噬细胞共同培养，则能够显著提升CD38的表达和活性。通过药物抑制衰老细胞相关分泌表型（SASP），则能够在体内降低组织内的CD38水平，并逆转NAD+水平的下降。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">由此可见，是细胞的衰老诱导了CD38+巨噬细胞的浸润和CD38表达的增加，并导致了后续NAD+的减少。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">LPS可诱导CD38依赖性的NAD+/NMN水平降低</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">那么CD38是如何让NAD+减少的呢？</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">正如前文所述，CD38的催化结构与NAD+身处“两个空间”，很显然它并不主要直接作用于NAD+，所以研究者们猜测，CD38很可能是与胞外的NAD+前体们存在一些关系，使得NAD+的生物合成减少。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">有趣的是，实验结果显示，在细胞内存在的少量CD38已经足以调节胞内NAD+的水平，而CD38同时还作用于胞外的NMN，阻止细胞对NMN的利用，而且这种作用仅与NMN有关，不影响其他的NAD+前体。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">使用CD38抗体治疗，则可以将老年小鼠白色脂肪组织内的NAD+水平提升到与年轻小鼠类似的水平，简直非常神奇。如果同时补充NMN，NAD+水平还能够得到进一步的改善。</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">CD38抗体和补充NMN可以提升年老小鼠NAD+水平</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">当然了，根据数据，CD38并不是唯一的调控NAD+水平的通路，不过从目前来看，它是很有潜力的一个“治疗衰老”的靶点~</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">----</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>[https://mp.weixin.qq.com/s/AKFYn-AA5OqezbhArmKH9g 两篇《自然·代谢》：破解抗衰老分子NAD+消失之谜！科学家发现，衰老细胞诱导巨噬细胞产生的CD38消耗了NAD+]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>[https://mp.weixin.qq.com/s/AKFYn-AA5OqezbhArmKH9g 两篇《自然·代谢》：破解抗衰老分子NAD+消失之谜！科学家发现，衰老细胞诱导巨噬细胞产生的CD38消耗了NAD+]</div></td></tr> </table> 明华 http://wiki.sseuu.com/index.php?title=%E4%B8%A4%E7%AF%87%E3%80%8A%E8%87%AA%E7%84%B6%C2%B7%E4%BB%A3%E8%B0%A2%E3%80%8B%EF%BC%9A%E7%A0%B4%E8%A7%A3%E6%8A%97%E8%A1%B0%E8%80%81%E5%88%86%E5%AD%90NAD%2B%E6%B6%88%E5%A4%B1%E4%B9%8B%E8%B0%9C%EF%BC%81%E7%A7%91%E5%AD%A6%E5%AE%B6%E5%8F%91%E7%8E%B0%EF%BC%8C%E8%A1%B0%E8%80%81%E7%BB%86%E8%83%9E%E8%AF%B1%E5%AF%BC%E5%B7%A8%E5%99%AC%E7%BB%86%E8%83%9E%E4%BA%A7%E7%94%9F%E7%9A%84CD38%E6%B6%88%E8%80%97%E4%BA%86NAD%2B&diff=101376&oldid=prev 明华：创建页面，内容为“[https://mp.weixin.qq.com/s/AKFYn-AA5OqezbhArmKH9g 两篇《自然·代谢》：破解抗衰老分子NAD+消失之谜！科学家发现，衰老细胞诱导巨噬细...” 2021-04-15T05:41:23Z <p>创建页面，内容为“[https://mp.weixin.qq.com/s/AKFYn-AA5OqezbhArmKH9g 两篇《自然·代谢》：破解抗衰老分子NAD+消失之谜！科学家发现，衰老细胞诱导巨噬细...”</p> <p><b>新页面</b></p><div>[https://mp.weixin.qq.com/s/AKFYn-AA5OqezbhArmKH9g 两篇《自然·代谢》：破解抗衰老分子NAD+消失之谜！科学家发现，衰老细胞诱导巨噬细胞产生的CD38消耗了NAD+]</div> 明华